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KMID : 0354619940060020225
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Journal Dankook Dental Research Institute
1994 Volume.6 No. 2 p.225 ~ p.236
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The Experimental Study on the Effect of Estrogen on Osteoporosis in Ovariectomized Rats
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Abstract
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Osteoporosis is a state of reduced bone mass per unit volume with a normal ratio of mineral to matrix. There were many methods for osteoporosis, and estrogen is one of then.
In this study, 30 female rats were ovariectomized to make a state of estrogen deficiency and induce osteoporosis After 13 weeks, 15 ovariectomized rats were injected 6 times with 60㎍/kg of estradiol by 1 week interval (experimental group). The
remaining 15 ovariectomized rats were used as control group. According to the time schedule, both of them were sacrified and femur were harvested. Paraffin sections were stained with Hematoxylin-Eosin staining and modified Gomori's Trichrome
staining,
and observed under light microscope.
@ES The results were as follows :
@EN 1. There were no significant bony changes between the experimentla and control group of cancellous bone.
2. The density of cortical bone showed increasing with time in experimental group.
3. The resorption of cortical bone in experimental group was less than that of control group.
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KEYWORD
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